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Toll-like Receptor 3 Activation Decreases Porcine Arterivirus Infection

1 Sept 2008

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that initiates infection in pulmonary alveolar macrophages (PAMs), elicits weak immune responses, and establishes a persistent infection. To understand the role of dsRNA intermediates in eliciting host immunity, we sought to determine if toll-like receptor-3 (TLR3), a well-known dsRNA sensor, is involved in the regulation of PRRSV...

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PMID: 18788939
DOI: 10.1089/vim.2008.0042

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