Article
Production of donor-derived sperm after spermatogonial stem cell transplantation in the dog.
Reproduction (Cambridge, England) - 1 Dec 2008
Kim Yeunhee, Turner Danielle, Nelson Jacquelyn, Dobrinski Ina, McEntee Margaret, Travis Alexander J
Abstract excerpt
Spermatogonial stem cell transplantation (SSCT) offers unique approaches to investigate SSC and to manipulate the male germline. We report here the first successful performance of this technique in the dog, which is an important model of human diseases. First, we investigated an irradiation protocol to deplete endogenous male germ cells in recipient testes. Histologic examination confirmed >95% depletion of...
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