Article
The knock-out of ARP3a gene affects F-actin cytoskeleton organization altering cellular tip growth, morphology and development in moss Physcomitrella patens.
Cell motility and the cytoskeleton - 1 Oct 2008
Finka Andrija, Saidi Younousse, Goloubinoff Pierre, Neuhaus Jean-Marc, Zrÿd Jean-Pierre, Schaefer Didier G
Abstract excerpt
The seven subunit Arp2/3 complex is a highly conserved nucleation factor of actin microfilaments. We have isolated the genomic sequence encoding a putative Arp3a protein of the moss Physcomitrella patens. The disruption of this ARP3A gene by allele replacement has generated loss-of-function mutants displaying a complex developmental phenotype. The loss-of function of ARP3A gene results in shortened, almost cubic...
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