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Article

Predisposition of genetic disease by modestly decreased expression of GCH1 mutant allele.

Experimental & molecular medicine - 30 Jun 2008

Kim Yo Sik, Choi Yong Bock, Lee Jeong Hwa, Yang Sei Hoon, Cho Ji Hyun, Shin Chang Ho, Lee Sang Do, Paik Moon Kee, Hong Kyeong Man

Abstract excerpt

Recently it was shown that single nucleotide polymorphisms (SNPs) can explain individual variation because of the small changes of the gene expression level and that the 50% decreased expression of an allele might even lead to predisposition to cancer. In this study, we found that a decreased exp...

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Identifiers

PMID: 18587264
DOI: 10.3858/emm.2008.40.3.271
PMCID: PMC2679294

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18587264-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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