The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis.

doi:10.1371/journal.pone.0002533

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Article

The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis.

PloS one - 25 Jun 2008

Zafarmand Mohammad Hadi, van der Schouw Yvonne T, Grobbee Diederick E, de Leeuw Peter W, Bots Michiel L

Abstract excerpt

BACKGROUND: The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD). METHODOLOGY/PRINCIPAL FINDINGS: A case-cohort study was conducted in 1,732 unrelated middle-age women (210 CHD cases and 1,522 controls) from a prospective cohort of 15,236 initially healthy Dutch women. We applied a Cox...

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PMID: 18575631
DOI: 10.1371/journal.pone.0002533
PMCID: PMC2432037

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