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Article

Parkinsonism in FMR1 premutation carriers may be indistinguishable from Parkinson disease.

Parkinsonism & related disorders - 1 Feb 2009

Hall Deborah A, Howard Katherine, Hagerman Randi, Leehey Maureen A

Abstract excerpt

Premutation carriers of repeat expansions in the fragile X mental retardation (FMR1) gene develop kinetic tremor and ataxia or the 'fragile X associated tremor/ataxia syndrome' (FXTAS). Affected FMR1 premutation carriers also have parkinsonism, but have not been reported to meet criteria for Parkinson disease. This case series illustrates that some patients who are FMR1 premutation carriers may appear by history...

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Source

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Identifiers

PMID: 18565783
DOI: 10.1016/j.parkreldis.2008.04.037
PMCID: PMC2685192

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Parkinsonism in FMR1 premutation carriers may be indistinguishable from Parkinson disease.PMID 18565783Read ↗

Screening for the presence of FMR1 premutation alleles in women with parkinsonism.Semantic proximity Read ↗

Parkinsonism, FXTAS, and FMR1 premutations.Semantic proximity Read ↗

Screen for excess FMR1 premutation alleles among males with parkinsonism.Semantic proximity Read ↗

Premutations in the FMR1 gene in Serbian patients with undetermined tremor, ataxia and parkinsonism.Semantic proximity Read ↗

FXTAS is rare among Portuguese patients with movement disorders: FMR1 premutations may be associated with a wider spectrum of phenotypes.Semantic proximity Read ↗

Premutations in the FMR1 gene are uncommon in men undergoing genetic testing for spinocerebellar ataxia.Semantic proximity Read ↗

Frequency of FMR1 premutation in individuals with ataxia and/or tremor and/or parkinsonism.Semantic proximity Read ↗

Carriage of One or Two FMR1 Premutation Alleles Seems to Have No Effect on Illness Severity in a FXTAS Female with an Autozygous FMR1 Premutation Allele.Semantic proximity Read ↗

FMR1 premutations associated with fragile X-associated tremor/ataxia syndrome in multiple system atrophy.Semantic proximity Read ↗

Fragile X associated tremor/ataxia syndrome (FXTAS) with dementia in a female harbouring FMR1 premutation.Semantic proximity Read ↗

Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS): Pathophysiology and Clinical Implications.Semantic proximity Read ↗

Penetrance of the fragile X-associated tremor/ataxia syndrome in a premutation carrier population.Semantic proximity Read ↗

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