Article
Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome.
Pediatric nephrology (Berlin, Germany) - 1 Sept 2008
Chernin Gil, Heeringa Saskia F, Gbadegesin Rasheed, Liu Jinhong, Hinkes Bernward G, Vlangos Christopher N, Vega-Warner Virginia, Hildebrandt Friedhelm
Abstract excerpt
In African American (AA) children, focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome (NS). It has been shown that AA children suffer from FSGS and steroid-resistant nephrotic syndrome (SRNS) at a higher frequency and with a more severe renal outcome in comparison with Caucasian children. Previous mutation analysis of large cohorts revealed that a high percentage of childhood...
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