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Article

The pathological splicing mutation c.6792C>G in NF1 exon 37 causes a change of tenancy between antagonistic splicing factors.

FEBS letters - 25 Jun 2008

Skoko Natasa, Baralle Marco, Buratti Emanuele, Baralle Francisco E

Abstract excerpt

We have previously identified an ESE in NF1 exon 37 whose disruption by the pathological mutation c.6792C>G caused aberrant splicing. We now investigate the RNA-protein complexes affected by the c.6792C>G mutation observing that this concurrently decreases the affinity for the positive splicing factor YB-1 and increases the affinity for the negative splicing factors, hnRNPA1, hnRNPA2 and a new player in these...

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PMID: 18503770
DOI: 10.1016/j.febslet.2008.05.018

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DAZAP1

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