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Article

Spinocerebellar ataxia type 2 (SCA2): clinical features and genetic analysis.

Journal of tropical pediatrics - 1 Oct 2008

Mutesa Léon, Pierquin Geneviève, Segers Karin, Vanbellinghen Jean François, Gahimbare Laetitia, Bours Vincent

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease that results from the expansion of an unstable trinucleotide CAG repeat encoding for a polyglutamine tract. In normal individuals, alleles contain between 14 and 31 CAG repeats, whereas the pathological alleles have more than 35 CAG repeats. The clinical phenotype of SCA2 includes a progressive cerebellar ataxia with...

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PMID: 18499737
DOI: 10.1093/tropej/fmn034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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