Article
Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis: differential diagnosis between refractory anemia and aplastic anemia.
Pathology international - 1 Jun 2008
Iwasaki Takashi, Murakami Masashi, Sugisaki Chiho, Sobue Sayaka, Ohashi Haruhiko, Asano Haruhiko, Suzuki Motoshi, Nakamura Shigeo, Ito Masafumi, Murate Takashi
Abstract excerpt
P53 mutation has been reported in various solid tumors, acute leukemia and myelodysplastic syndrome (MDS), but the diagnostic significance of p53 in MDS remains to be determined. The purpose of the present paper was to examine p53 mutation and immunostaining of the same patients, because there have been few reports of simultaneous analysis of these markers. Seven p53 mutations were observed among 37 MDS and 11...
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