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Article

Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

Biochemistry - 10 Jun 2008

Zhu Weidong, Lin Alexander, Banerjee Ruma

Abstract excerpt

Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme, which functions in the transsulfuration pathway that converts homocysteine to cysteine. In addition, CGL is one of two major enzymes that can catalyze the formation of hydrogen sulfide, an important gaseous signaling molecule. Recently, several mutations in CGL have been described in patients with cystathioninuria, a rare...

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PMID: 18476726
DOI: 10.1021/bi800351a
PMCID: PMC2910112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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