Article
Identification and diversity of putative aminoglycoside-biosynthetic aminotransferase genes from deep-sea environmental DNA.
Bioscience, biotechnology, and biochemistry - 1 May 2008
Aoki Rie, Nagaya Atsushi, Arakawa Shizuka, Kato Chiaki, Tamegai Hideyuki
Abstract excerpt
We obtained DNA fragments encoding putative aminotransferases possibly involved in the biosynthesis of aminoglycoside antibiotics from deep-sea sediments of the northwest Pacific Ocean by nested PCR, and 34 individual genes (total 89 clones) were identified. About half of the deep-sea sequences showed similarity with genes of known aminoglycoside-producers, but others were deep-sea specific genes. Furthermore, we...
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