Article
Evidence of gene conversion in the evolutionary process of the codon 41/42 (-CTTT) mutation causing beta-thalassemia in southern China.
Journal of molecular evolution - 1 May 2008
Zhang Wen, Cai Wang-Wei, Zhou Wei-Ping, Li Hai-Peng, Li Liang, Yan Wei, Deng Qin-Kai, Zhang Ya-Ping, Fu Yun-Xin, Xu Xiang-Min
Abstract excerpt
The 4-bp deletion (-CTTT) at codon 41/42 (CD41/42) of the human beta-globin gene represents one of the most common beta-thalassemia mutations in East Asia and Southeast Asia, which is historically afflicted with endemic malaria, thus hypothetically evolving under natural selection by malaria infection. To understand the evolutionary process of generating the beta(CD41/42) allele and its maintenance, including the...
Topics
- Base Sequence
- China
- Codon
- DNA Mutational Analysis
- Evolution, Molecular
- Gene Conversion
- Genetic Variation
- Globins
- Haplotypes
- Humans
- Models, Genetic
- Mutation
- Polymorphism, Genetic