Article
Phenotypic identification of platelet-type von Willebrand disease and its discrimination from type 2B von Willebrand disease: a question of 2B or not 2B? A story of nonidentical twins? Or two sides of a multidenominational or multifaceted primary-hemostasis coin?
Seminars in thrombosis and hemostasis - 1 Feb 2008
Favaloro Emmanuel J
Abstract excerpt
Platelet-type von Willebrand disease (PT-VWD) and type 2B von Willebrand disease (2B-VWD) have different etiologies although both present with a similar clinical bleeding and basic laboratory phenotype. Both PT-VWD and 2B-VWD represent gain-of-function mutations that lead to enhanced binding between plasma von Willebrand factor (VWF) and its platelet ligand, glycoprotein Ib alpha (GP1BA). However, 2B-VWD results...
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