Article
Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder.
Biological psychiatry - 15 Jun 2008
Christian Susan L, Brune Camille W, Sudi Jyotsna, Kumar Ravinesh A, Liu Shaung, Karamohamed Samer, Badner Judith A, Matsui Seiichi, Conroy Jeffrey, McQuaid Devin, Gergel James, Hatchwell Eli, Gilliam T Conrad, Gershon Elliot S, Nowak Norma J, Dobyns William B, Cook Edwin H
Abstract excerpt
BACKGROUND: One genetic mechanism known to be associated with autism spectrum disorders (ASD) is chromosomal abnormalities. The identification of copy number variants (CNV), i.e., microdeletions and microduplications that are undetectable at the level of traditional cytogenetic analysis, allows the potential association of submicroscopic chromosomal imbalances and human disease. METHODS: We performed array...
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