Article
Genetic mutations that prevent pain: implications for future pain medication.
Pharmacogenomics - 1 Feb 2008
Oertel Bruno, Lötsch Jörn
Abstract excerpt
Part of the interindividual variability in pain therapy has been associated with genetic polymorphisms. Several genetic variants prevent or at least decrease pain in their carriers as compared with carriers of the respective wild-type or common alleles by impeding the generation, transmission and processing of nociceptive information or by increasing the local availability of active analgesics or their...
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