Article
Characterization of trisomic natural killer cell abnormalities in a patient with constitutional trisomy 8 mosaicism.
Pediatric hematology and oncology - 1 Mar 2008
Marti Salvador, Galan Francisco M, Casero Jesus M, Merino Jaime, Rubio Gonzalo
Abstract excerpt
Malignancies found in children and adults with constitutional trisomy 8 mosaicism (CT8M) could be in part the consequence of dysfunction of trisomic immune cells. An adult patient exhibiting trisomy in the entire natural killer (NK) cell population has made possible the characterization of trisomy 8-positive NK cells. The study showed normal cytotoxic activity but predominance of an immunosenescent phenotype...
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