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Article

Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells.

Molecular cancer therapeutics - 1 Mar 2008

Kim Hwang-Phill, Han Sae-Won, Kim Sung-Hak, Im Seock-Ah, Oh Do-Youn, Bang Yung-Jue, Kim Tae-You

Abstract excerpt

Although non-small cell lung cancer (NSCLC) cells with somatic mutations in their epidermal growth factor receptors (EGFR) initially show a dramatic response to tyrosine kinase inhibitor (TKI), these cells eventually develop resistance to TKI. This resistance may be caused by a secondary T790M mutation in the EGFR tyrosine kinase, which leads to the substitution of methionine for threonine in 790. In this study,...

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Share to Antibodies, Monoclonal, Humanized
Share to Cetuximab

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

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Share to Gefitinib

Share to Genes, erbB-2

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Source

Identifiers

PMID: 18347147
DOI: 10.1158/1535-7163.MCT-07-2068

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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