Article
Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation.
Diabetic medicine : a journal of the British Diabetic Association - 1 Apr 2008
Murphy R, Turnbull D M, Walker M, Hattersley A T
Abstract excerpt
Maternally inherited diabetes and deafness (MIDD) affects up to 1% of patients with diabetes but is often unrecognized by physicians. It is important to make an accurate genetic diagnosis, as there are implications for clinical investigation, diagnosis, management and genetic counselling. This review summarizes the range of clinical phenotypes associated with MIDD; outlines the advances in genetic diagnosis and...
Topics
- Adult
- Corneal Dystrophies, Hereditary
- DNA, Mitochondrial
- Deafness
- Diabetes Mellitus
- Female
- Genetic Predisposition to Disease
- Genomic Imprinting
- Humans
- Male
- Mitochondrial Diseases
- Point Mutation
- Pregnancy
- Sex Factors