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GlialCAM, an immunoglobulin‐like cell adhesion molecule is expressed in glial cells of the central nervous system

21 Feb 2008

Abstract excerpt

Using structure based genome mining targeting vascular endothelial and platelet derived growth factor immunoglobulin (Ig) like folds, we have identified a sequence corresponding to a single transmembrane protein with two Ig domains, which we cloned from a human brain cDNA library. The cDNA is identical to hepatocyte cell adhesion molecule (hepaCAM), which was originally described as a tumor suppressor gene in...

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PMID: 18293412
DOI: 10.1002/glia.20640

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GlialCAM, an immunoglobulin‐like cell adhesion molecule is expressed in glial cells of the central nervous systemPMID 18293412Read ↗

GlialCAM Cytoplasmic Signaling in Oligodendrocytes and Astrocytes is Essential for White Matter Homeostasis in the BrainSemantic proximity Read ↗

Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.Semantic proximity Read ↗

Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins.Semantic proximity Read ↗

Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit.Semantic proximity Read ↗

HepaCAM Suppresses Glioblastoma Stem Cell Invasion in the BrainSemantic proximity Read ↗

Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans.Semantic proximity Read ↗

Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy.Semantic proximity Read ↗

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.Semantic proximity Read ↗

SETA: A novel SH3 domain-containing adapter molecule associated with malignancy in astrocytesSemantic proximity Read ↗

Exon 2 of the gene for neural cell adhesion molecule L1 is alternatively spliced in B cells.Semantic proximity Read ↗

Structural basis for the dominant or recessive character of GLIALCAM mutations found in leukodystrophies.Semantic proximity Read ↗

Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.Semantic proximity Read ↗

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