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Article

Adaptations to climate in candidate genes for common metabolic disorders.

PLoS genetics - 1 Feb 2008

Hancock Angela M, Witonsky David B, Gordon Adam S, Eshel Gidon, Pritchard Jonathan K, Coop Graham, Di Rienzo Anna

Abstract excerpt

Evolutionary pressures due to variation in climate play an important role in shaping phenotypic variation among and within species and have been shown to influence variation in phenotypes such as body shape and size among humans. Genes involved in energy metabolism are likely to be central to heat and cold tolerance. To test the hypothesis that climate shaped variation in metabolism genes in humans, we used a...

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Source

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Identifiers

PMID: 18282109
DOI: 10.1371/journal.pgen.0040032
PMCID: PMC2242814

Genes

FABP2
LEPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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