Article
Novel mutation and polymorphism of PRSS1 gene in the Chinese patients with hereditary pancreatitis and chronic pancreatitis.
Chinese medical journal - 20 Jan 2008
Liu Qi-cai, Gao Feng, Ou Qi-shui, Zhuang Ze-hao, Lin Shou-rong, Yang Bin, Cheng Zu-jian
Abstract excerpt
BACKGROUND: Mutations in the cationic trypsinogen gene (PRSS1) have been detected in patients with hereditary pancreatitis (HP). This study investigated the prevalence of the R122H (c.365 G > A), A121T (c.361 G > A) and D162D (c.488 C > T) mutations or polymorphisms in the common, non-hereditary forms of chronic pancreatitis and in an HP family. METHODS: DNA was prepared from blood samples of 54 patients with...
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