HSD3B1 as a Novel Trophoblast-associated Marker That Assists in the Differential Diagnosis of Trophoblastic Tumors and Tumorlike Lesions

Abstract excerpt

Trophoblastic tumors and tumorlike lesions can be confused with a variety of nontrophoblastic tumors; therefore, a trophoblast-associated marker that is expressed in all types of trophoblastic lesions is useful in differential diagnosis. In this report, we assessed the potential of hydroxyl-delta-5-steroid dehydrogenase (HSD3B1), an enzyme that catalyzes the oxidative conversion of delta-5-3 beta-hydroxy steroids...

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