Article
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.
The Plant cell - 1 Jan 2008
Lee Jae-Hoon, Terzaghi William, Gusmaroli Giuliana, Charron Jean-Benoit F, Yoon Hye-Jin, Chen Haodong, He Yizhou Joseph, Xiong Yue, Deng Xing Wang
Abstract excerpt
A subset of WD40 proteins that contain a DWD motif (for DDB1 binding WD40) is reported to act as substrate receptors for DDB1-CUL4-ROC1 (for Damaged DNA Binding 1-Cullin 4-Regulator of Cullins 1) based E3 ubiquitin ligases in humans. Here, we report 85 Arabidopsis thaliana and 78 rice (Oryza sativa) proteins containing the conserved 16-amino acid DWD motif. We show by yeast two-hybrid and in vivo...
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