Article
Genetic characterization of complex inter-recombinant HIV-1 strains circulating in Spain and reliability of distinct rapid subtyping tools.
Journal of medical virology - 1 Mar 2008
Holguín Africa, Lospitao Eva, López Marisa, de Arellano Eva Ramírez, Pena María José, del Romero Jorge, Martín Cristina, Soriano Vincent
Abstract excerpt
Genetic recombination and high rate of mutation increase HIV-1 diversity, allowing viruses to escape more easily from the host immune response or antiretroviral drugs. The recombinant nature of full-length HIV-1 genomic sequences derived from viruses infecting five epidemiologically unlinked individuals carrying HIV-1 non-B variants was investigated. Overlapping PCR amplifications followed by direct sequencing of...
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