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Article

Genetic variations and treatments that affect the lifespan of the NPC1 mouse.

Journal of lipid research - 1 Mar 2008

Liu Benny, Li Hao, Repa Joyce J, Turley Stephen D, Dietschy John M

Abstract excerpt

Niemann-Pick type C (NPC) disease is a multisystem disorder caused primarily by a mutation in the npc1 gene. These studies evaluated the effect of genetic background, deletion of additional genes, and administration of several agents on the age at death in a murine model of this disorder. Such factors as differing strain background or genetic drift within a given background in the npc1(-/-) mouse significantly...

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Liver X Receptors
Longevity
Neurodegenerative Diseases
Niemann-Pick C1 Protein
Niemann-Pick Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Orphan Nuclear Receptors

Receptors, Cytoplasmic and Nuclear

Sialyltransferases

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Identifiers

PMID: 18077828
DOI: 10.1194/jlr.M700525-JLR200

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Genetic variations and treatments that affect the lifespan of the NPC1 mouse.PMID 18077828Read ↗

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