[Molecular mechanism of thyroid carcinogenesis].

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Article

[Molecular mechanism of thyroid carcinogenesis].

Nihon rinsho. Japanese journal of clinical medicine - 1 Nov 2007

Yamashita Shunichi, Mitsutake Norisato

Abstract excerpt

Molecular mechanism of thyroid carcinogenesis has been well studied through the discovery of genetic abnormalities such as RET/PTC rearrangement and BRAF mutation, both of which constitutively activate MAP kinase pathway and are frequently found in papillary thyroid cancer. The TP53 mutation is thought to play a critical role in transformation of differentiated thyroid cancer into anaplastic thyroid cancer....

Topics

Adenocarcinoma, Papillary
Cell Transformation, Neoplastic
Extracellular Signal-Regulated MAP Kinases
Gene Rearrangement
Humans
Mutation
Neoplastic Stem Cells
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-ret
Receptors, G-Protein-Coupled
Thyroid Neoplasms
Tumor Suppressor Protein p53
Taste Receptors, Type 2

Source

Open in PubMed

Identifiers

PMID: 18018555

Genes

BRAF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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