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Article

Unique properties of Plasmodium falciparum porphobilinogen deaminase.

The Journal of biological chemistry - 4 Jan 2008

Nagaraj Viswanathan Arun, Arumugam Rajavel, Gopalakrishnan Bulusu, Jyothsna Yeleswarapu Sri, Rangarajan Pundi N, Padmanaban Govindarajan

Abstract excerpt

The hybrid pathway for heme biosynthesis in the malarial parasite proposes the involvement of parasite genome-coded enzymes of the pathway localized in different compartments such as apicoplast, mitochondria, and cytosol. However, knowledge on the functionality and localization of many of these enzymes is not available. In this study, we demonstrate that porphobilinogen deaminase encoded by the Plasmodium...

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PMID: 17962188
DOI: 10.1074/jbc.M706861200

Genes

UROS

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