Genetic Study of Saudi Diabetes (GSSD): significant association of the <i>KCNJ11</i> E23K polymorphism with type 2 diabetes

Abstract excerpt

BACKGROUND: The E23K variant of KCNJ11 has been associated with type 2 diabetes (T2D) in several but not all populations studied. Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established. METHODS: We performed a case-control association study using 550 T2D Saudi patients (WHO criteria), and 335 controls (age>or=60; fasting plasma glucose<7 mmol/L). E23K genotyping was...

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