Article
SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach.
BMC genomics - 6 Aug 2007
McCauley Jacob L, Kenealy Shannon J, Margulies Elliott H, Schnetz-Boutaud Nathalie, Gregory Simon G, Hauser Stephen L, Oksenberg Jorge R, Pericak-Vance Margaret A, Haines Jonathan L, Mortlock Douglas P
Abstract excerpt
BACKGROUND: Although genes play a key role in many complex diseases, the specific genes involved in most complex diseases remain largely unidentified. Their discovery will hinge on the identification of key sequence variants that are conclusively associated with disease. While much attention has been focused on variants in protein-coding DNA, variants in noncoding regions may also play many important roles in...
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