Article
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation.
Human molecular genetics - 1 Sept 2007
Luzón-Toro Berta, Rubio de la Torre Elena, Delgado Asunción, Pérez-Tur Jordi, Hilfiker Sabine
Abstract excerpt
Pathogenic mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant and certain cases of sporadic Parkinson's disease (PD). The G2019S substitution in LRRK2 is the most common genetic determinant of PD identified so far, and maps to a specific region of the kinase domain called the activation segment. Here, we show that autophosphorylation of LRRK2 is an intermolecular reaction and...
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