Article
Mutations of the RAG3 gene encoding a regulator of fermentation in Kluyveromyces lactis are suppressed by a mutation of the transcription factor gene KlGCR1.
FEMS yeast research - 1 Aug 2007
Tizzani Lorenza, Wésolowski-Louvel Micheline, Forte Valentina, Romitelli Federica, Salani Francesca, Lemaire Marc, Neil Helen, Bianchi Michele M
Abstract excerpt
In Kluyveromyces lactis, Rag3 regulates both fermentative metabolism and thiamine biosynthesis. Regulation of fermentation is exerted at the level of transcription of KlPDC1. We have isolated and identified a mutation of the transcription factor KlGCR1, Klgcr1-1, which suppressed the fermentative-deficient phenotype associated with the RAG3 deletion. In the mutant, the transcription of KlPDC1 was restored....
Topics
- DNA-Binding Proteins
- Fermentation
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Kluyveromyces
- Mutation
- Pyruvate Decarboxylase
- Transcription Factors
- Transcription, Genetic