Article
The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis.
Journal of virology - 1 Jun 2007
Isomura Hiroki, Stinski Mark F, Kudoh Ayumi, Nakayama Sanae, Iwahori Satoko, Sato Yoshitaka, Tsurumi Tatsuya
Abstract excerpt
Transcription of the DNA polymerase processivity factor gene (UL44) of human cytomegalovirus initiates at three distinct start sites, which are differentially regulated during productive infection. Two of these start sites, the distal and proximal sites, are active at early times, and the middle start site is active at only late times after infection (F. Leach and E. S. Mocarski, J. Virol. 63:1783-1791, 1989)....
Topics
- Binding Sites
- Cytomegalovirus
- DNA, Viral
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Fibroblasts
- Humans
- Kanamycin
- Models, Genetic
- Mutagenesis