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Article

Role of Autophagy in Innate Viral Recognition

16 Jul 2007

Abstract excerpt

Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes via Toll-like receptors (TLRs) upon endocytosis of virions. Yet, pDC responses to certain single-stranded RNA viruses occur only following live viral infection. In our recent study, we presented evidence that the recognition of such viruses by TLR7 requires autophagy. We speculate that the requirement for autophagy in viral recognition...

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PMID: 17404496
DOI: 10.4161/auto.4114

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