Article
Effects of chromosomal variations on pharmacokinetic activity of zolpidem in healthy volunteers: an array-based comparative genomic hybridization study.
Biochemical and biophysical research communications - 18 May 2007
Moon Ho-Jin, Choi Jin Soo, Park E-Jin, Kang Chin-Yang, Jeon Yang-Whan, Lee Kweon-Haeng, Rha Hyoung Kyun, Han Sang-Ick
Abstract excerpt
Zolpidem has been known as a very safe and effective hypnotic drug used to treat a variety of patients with insomnia. Even though the same dose of the medicine is administered to each patient, the blood level of zolpidem and the time required to obtain peak concentration are not consistent among different people. We evaluated the relationship between the peak concentrations of zolpidem and chromosomal imbalances...
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