Article
Emerging strategies for the treatment of mutant Bcr-Abl T315I myeloid leukemia.
Clinical lymphoma & myeloma - 1 Mar 2007
Mughal Tariq I, Goldman John M
Abstract excerpt
The lessons learned from the remarkably successful use of the first-generation tyrosine kinase inhibitor (TKI) imatinib in patients with chronic myeloid leukemia resulted in a major paradigm shift in the treatment of many human cancers, and now further lessons are being learned from our enhanced understanding of the molecular mechanisms of resistance to imatinib and second-generation TKIs, particularly dasatinib...
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