Tyrosinase and ocular diseases: some novel thoughts on the molecular basis of oculocutaneous albinism type 1.

doi:10.1016/j.preteyeres.2007.01.001

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Article

Tyrosinase and ocular diseases: some novel thoughts on the molecular basis of oculocutaneous albinism type 1.

Progress in retinal and eye research - 1 Jul 2007

Ray Kunal, Chaki Moumita, Sengupta Mainak

Abstract excerpt

Tyrosinase (TYR) is a multifunctional copper-containing glycoenzyme (approximately 80 kDa), which plays a key role in the rate-limiting steps of the melanin biosynthetic pathway. This membrane-bound protein, possibly evolved by the fusion of two different copper-binding proteins, is mainly expressed in epidermal, ocular and follicular melanocytes. In the melanocytes, TYR functions as an integrated unit with other...

Topics

Albinism, Oculocutaneous
Animals
DNA
Gene Expression
Humans
Monophenol Monooxygenase
Phenotype

Source

Open in PubMed

Identifiers

PMID: 17355913
DOI: 10.1016/j.preteyeres.2007.01.001

Genes

TYR
LAMP1
TYRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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