Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

8 Mar 2007

Abstract excerpt

Several strategies have been pursued to increase the extent of exon 7 inclusion during splicing of SMN2 (survival of motor neuron 2) transcripts, for eventual therapeutic use in spinal muscular atrophy (SMA), a genetic neuromuscular disease. Antisense oligonucleotides (ASOs) that target an exon or its flanking splice sites usually promote exon skipping. Here we systematically tested a large number of ASOs with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17355180
DOI: 10.1371/journal.pbio.0050073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the ExonPMID 17355180Read ↗

Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophySemantic proximity Read ↗

Improved Antisense Oligonucleotide Design to Suppress Aberrant SMN2 Gene Transcript Processing: Towards a Treatment for Spinal Muscular AtrophySemantic proximity Read ↗

Antisense oligonucleotide mediated therapy of spinal muscular atrophySemantic proximity Read ↗

Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3' splice site pairing.Semantic proximity Read ↗

Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates <i>SMN2</i> gene expression in patient fibroblastsSemantic proximity Read ↗

Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs.Semantic proximity Read ↗

Antisense Oligonucleotides for the Treatment of Spinal Muscular AtrophySemantic proximity Read ↗

Dual Masking of Specific Negative Splicing Regulatory Elements Resulted in Maximal Exon 7 Inclusion of SMN2 GeneSemantic proximity Read ↗

Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscapeSemantic proximity Read ↗

High Concentration of an ISS-N1-Targeting Antisense Oligonucleotide Causes Massive Perturbation of the TranscriptomeSemantic proximity Read ↗

Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse modelsSemantic proximity Read ↗

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.