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Article

Amplification and characterization of the retinoblastoma gene VNTR by PCR.

American journal of human genetics - 1 Feb 1992

Scharf S J, Bowcock A M, McClure G, Klitz W, Yandell D W, Erlich H A

Abstract excerpt

VNTR regions are informative genetic markers for linkage mapping and individual identification. Using PCR, we have developed a procedure for the enzymatic amplification of the VNTR located in the 16th intron of the human retinoblastoma (RB1) gene. We have also prepared a nonisotopically labeled oligonucleotide probe which facilitates detection of the amplification products. In examining 250 individuals from four...

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PMID: 1734717
PMCID: PMC1682449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Amplification and characterization of the retinoblastoma gene VNTR by PCR.PMID 1734717Read ↗

Utilization of a polymorphic variable-number-tandem-repeat DNA region within the RB1 gene for early diagnosis of hereditary retinoblastoma.Semantic proximity Read ↗

Identification of germline mutations in the RB1 gene by denaturant gradient gel electrophoresis and polymerase chain reaction direct sequencing.Semantic proximity Read ↗

Mutational screening of the RB1 gene in Indian patients with retinoblastoma reveals eight novel and several recurrent mutations.Semantic proximity Read ↗

Five novel single nucleotide polymorphisms of the RB1 gene (g.5625T>C, g.70169T>G, g.76875A>T, g.78026delA, and g.150072T>C) in retinoblastoma patients.Semantic proximity Read ↗

A previously unknown polymorphism located within the RB1 locus only present in Asian individuals.Semantic proximity Read ↗

Two new mutations and three novel polymorphisms in the RB1 gene in Ecuadorian patients.Semantic proximity Read ↗

Germline mutations in the RB1 gene in patients with hereditary retinoblastoma.Semantic proximity Read ↗

PCR-based detection of a polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) geneSemantic proximity Read ↗

Mutational analysis of the RB1 gene in Indian patients with retinoblastoma.Semantic proximity Read ↗

Identification of three novel RB1 mutations in Brazilian patients with retinoblastoma by "exon by exon" PCR mediated SSCP analysis.Semantic proximity Read ↗

Identification of novel mutations in the RB1 gene in Mexican patients with retinoblastoma.Semantic proximity Read ↗

[Spectrum and frequencies of RB1 gene structural defects in retinoblastoma].Semantic proximity Read ↗

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