Article
Insights into extensive deletions around the XK locus associated with McLeod phenotype and characterization of two novel cases.
Gene - 1 May 2007
Peng Jianbin, Redman Colvin M, Wu Xu, Song Xiaoling, Walker Ruth H, Westhoff Connie M, Lee Soohee
Abstract excerpt
The McLeod phenotype is derived from various forms of XK gene defects that result in the absence of XK protein, and is defined hematologically by the absence of Kx antigen, weakening of Kell system antigens, and red cell acanthocytosis. Individuals with the McLeod phenotype usually develop late-onset neuromuscular abnormalities known as the McLeod syndrome (MLS). MLS is an X-linked multi-system disorder caused by...
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