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Article

Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.

Structure (London, England : 1993) - 1 Feb 2007

Foulkes-Murzycki Jennifer E, Scott Walter Robert Peter, Schiffer Celia A

Abstract excerpt

Hydrophobic residues outside the active site of HIV-1 protease frequently mutate in patients undergoing protease inhibitor therapy; however, the mechanism by which these mutations confer drug resistance is not understood. From analysis of molecular dynamics simulations, 19 core hydrophobic residues appear to facilitate the conformational changes that occur in HIV-1 protease. The hydrophobic core residues slide by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17292840
DOI: 10.1016/j.str.2007.01.006
PMCID: PMC2044563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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