Article
A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders.
Molecular diagnosis & therapy - 1 Jan 2007
Coon Keith D, Dunckley Travis L, Stephan Dietrich A
Abstract excerpt
Genetically complex disorders continue to confound investigators because of their many underlying factors, both genetic and environmental. In order to tease apart the heritable from the non-heritable contributions to disease, clinicians are relying on researchers in the rapidly expanding fields of high-throughput genomics to identify surrogate clinical endpoints, called biomarkers, that provide a measure of the...
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