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Article

Preclinical validation of a multiplex real-time assay to quantify SMN mRNA in patients with SMA.

Neurology - 6 Feb 2007

Simard L R, Bélanger M-C, Morissette S, Wride M, Prior T W, Swoboda K J

Abstract excerpt

OBJECTIVE: To determine whether survival motor neuron (SMN) expression was stable over time. METHODS: We developed a multiplex real-time reverse transcriptase (RT)-PCR assay to quantify SMN transcripts in preclinical blood samples from 42 patients with spinal muscular atrophy (SMA) drawn for three time points per patient; most blood samples were shipped to a centralized laboratory. RESULTS: We obtained a...

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Identifiers

PMID: 17283322
DOI: 10.1212/01.wnl.0000252934.70676.ab
PMCID: PMC3273325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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