Article
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.
European journal of neurology - 1 Jan 2007
Xiromerisiou G, Hadjigeorgiou G M, Gourbali V, Johnson J, Papakonstantinou I, Papadimitriou A, Singleton A B
Abstract excerpt
Mutations in SNCA and LRRK2 genes, encoding alpha-synuclein and leucine-rich repeat kinase 2, respectively, cause autosomal dominant Parkinson's disease (AdPD). The LRRK2 G2019S (c.6055G > A) and R1441G (c.4321C > G) mutations have also been identified in sporadic PD (sPD). We studied 55 unrelate...
Topics
- Adult
- Aged
- Aged, 80 and over
- Female
- Genetic Testing
- Genetic Variation
- Greece
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Parkinsonian Disorders
- Protein Serine-Threonine Kinases
- alpha-Synuclein