Article
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2007
Concolino Paola, Capoluongo Ettore, Santonocito Concetta, Vento Giovanni, Tana Milena, Romagnoli Costantino, Zuppi Cecilia, Ameglio Franco, Brancaccio Andrea, Sciandra Francesca
Abstract excerpt
BACKGROUND: Dystroglycan (DG) is an extracellular matrix receptor that serves as an adhesion molecule and is essential for the stability of the plasma membrane. DG is highly expressed within the epithelial cell layer where it supports morphogenesis, adhesion and wound repair. Mechanically ventilated newborns often develop bronchopulmonary dysplasia (BPD), characterized by a progressive impairment of wound repair...
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