Article
Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.
Neurology - 28 Nov 2006
Kamm C, Asmus F, Mueller J, Mayer P, Sharma M, Muller U J, Beckert S, Ehling R, Illig T, Wichmann H E, Poewe W, Mueller J C, Gasser T
Abstract excerpt
Recently, association of a TOR1A(DYT1)/TOR1B risk haplotype with common forms of idiopathic dystonia has been reported in the Icelandic population. Here we report a strong association of two single nucleotide polymorphisms within or in close proximity to the TOR1A 3'UTR, with the lowest p value being 0.000008, in a larger cohort of German and Austrian patients with predominantly focal sporadic dystonia.
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