Article
The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesis.
Development (Cambridge, England) - 1 Dec 2006
Spitzer Christoph, Schellmann Swen, Sabovljevic Aneta, Shahriari Mojgan, Keshavaiah Channa, Bechtold Nicole, Herzog Michel, Müller Stefan, Hanisch Franz-Georg, Hülskamp Martin
Abstract excerpt
Recently, an alternative route to the proteasomal protein-degradation pathway was discovered that specifically targets transmembrane proteins marked with a single ubiquitin to the endosomal multivesicular body (MVB) and, subsequently, to the vacuole (yeast) or lysosome (animals), where they are degraded by proteases. Vps23p/TSG101 is a key component of the ESCRT I-III machinery in yeast and animals that...
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