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Article

Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening.

Journal of medical genetics - 1 Jan 2007

Smith A, Moran A, Boyd M C, Bulman M, Shenton A, Smith L, Iddenden R, Woodward E R, Lalloo F, Maher E R, Evans D G R

Abstract excerpt

BACKGROUND: The identification of BRCA1 and BRCA2 mutations in familial breast cancer kindreds allows genetic testing of at-risk relatives. Those who test negative are usually reassured and additional breast cancer surveillance is discontinued. However, we postulated that in high-risk families, s...

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Source

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Identifiers

PMID: 17079251
DOI: 10.1136/jmg.2006.043091
PMCID: PMC2597903

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17079251-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening.PMID 17079251Read ↗

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Phenocopy breast cancer rates in Israeli BRCA1 BRCA2 mutation carrier families: is the risk increased in non-carriers?Semantic proximity Read ↗

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA).Semantic proximity Read ↗

The clinical utility of genetic testing in breast cancer kindreds: a prospective study in families without a demonstrable BRCA mutation.Semantic proximity Read ↗

Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers.Semantic proximity Read ↗

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