Article
Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening.
Journal of medical genetics - 1 Jan 2007
Smith A, Moran A, Boyd M C, Bulman M, Shenton A, Smith L, Iddenden R, Woodward E R, Lalloo F, Maher E R, Evans D G R
Abstract excerpt
BACKGROUND: The identification of BRCA1 and BRCA2 mutations in familial breast cancer kindreds allows genetic testing of at-risk relatives. Those who test negative are usually reassured and additional breast cancer surveillance is discontinued. However, we postulated that in high-risk families, such as those seen in clinical genetics centres, the risk of breast cancer might be influenced not only by the...
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