Article
Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial.
The Journal of clinical endocrinology and metabolism - 1 Jan 2007
Blum Werner F, Crowe Brenda J, Quigley Charmian A, Jung Heike, Cao Dachuang, Ross Judith L, Braun LeeAnn, Rappold Gudrun
Abstract excerpt
BACKGROUND: The short stature homeobox-containing gene, SHOX, located on the distal ends of the X and Y chromosomes, encodes a homeodomain transcription factor responsible for a significant proportion of long-bone growth. Patients with mutations or deletions of SHOX, including those with Turner syndrome (TS) who are haplo-insufficient for SHOX, have variable degrees of growth impairment, with or without a...
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