Article
Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant.
Human genetics - 1 Dec 1990
Oppenheim A, Yaari A, Rund D, Rachmilewitz E A, Nathan D, Wong C, Kazazian H H, Miller B
Abstract excerpt
The mechanism for elevated production of fetal hemoglobin (Hb F) in a Druze patient with beta zero-thalassemia intermedia was investigated. Heterozygous family members exhibited normal Hb F levels, suggesting that the increase in gamma-gene expression in the propositus may be partly due to anemic...
Topics
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- DNA
- Ethnicity
- Female
- Fetal Hemoglobin
- Globins
- Humans
- Israel
- Male
- Middle Aged
- Mutation
- Nucleic Acid Hybridization
- Pedigree
- Thalassemia