Article
Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant.
Human genetics - 1 Dec 1990
Oppenheim A, Yaari A, Rund D, Rachmilewitz E A, Nathan D, Wong C, Kazazian H H, Miller B
Abstract excerpt
The mechanism for elevated production of fetal hemoglobin (Hb F) in a Druze patient with beta zero-thalassemia intermedia was investigated. Heterozygous family members exhibited normal Hb F levels, suggesting that the increase in gamma-gene expression in the propositus may be partly due to anemic stress. Erythroid progenitors of these family members cultured in vitro [burst forming units (erythroid); (BFUe)]...
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